Game: Battle Toads & Double Dragon

After being defeated by the Battletoads, the evil Dark Queen flees to the outer reaches of the universe and the 'Toads and their mentor get on with their lives. However, one day the Earth's military is neutralized and a giant spaceship called Colossus emerges from the moon. Apparently, the Dark Queen is back in another plan to dominate the galaxy, and she has allied herself with the Shadow Warriors (from the Double Dragon series) to supplement her forces. Deciding to even the odds, the Battletoads get in contact with Billy and Jimmy Lee and ask them for their help. The brothers agree, and all five immediately take off for the Colossus in a mission to stop this two-pronged threat