Zool 2 is very similar gameplay-wise to the original game, but with more cartoonish and detailed graphics. It added the option to play as Zool's female counterpart, Zooz. The two characters played similarly, although there were some subtle differences in their abilities. Most notably, Zool could destroy parts of the scenery that Zooz couldn't, and vice versa, resulting in a slightly different route through the level. The sequel, like the original, also featured several mini games. The most common was a version of Breakout which used Zool's two-headed pet dog as a paddle. The intergalactic alien ninja Zool returns, and this time his enemies in the game were named Krool and his assistant Mental Block, whose goal is to stifle the world's imagination, causing rampant boredom. In his fight Zool is aided by his female companion, named Zooz (in a red costume), and his faithful dog Zoon. The ending contained a hint at a possible further sequel.
Each game uses different controls, most DOS games use the keyboard arrows. Some will use the mouse , "Alt" ,"Enter" and "Space bar".